Mouse Frizzled Homolog 1 (FZD1) Protein
1235€ (100 µg)
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935106861
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name
Mouse Frizzled Homolog 1 (FZD1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692060
tested applications
SDS-PAGE
Description
Mouse Frizzled-1 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse FZD1 (NP_067432.2) extracellular domain (Met 1-His 248) was expressed with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Frizzled-1 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 21 kDa Sequence Fragment: Met1-His248 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_067432.2 |
| Alias | FDZ1,Fz1,Wnt receptor,frizzled family receptor 1,Frizzled-1 |
| Background | Protein FZD1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FZD1 is a member of the Frizzled family of G protein-coupled receptors (GPCRs) that function as receptors for Wnt signaling proteins. It is widely expressed in various tissues, including the kidney, brain, and bone, and plays a pivotal role in the canonical Wnt/β-catenin pathway and non-canonical pathways like planar cell polarity (PCP) and calcium signaling. FZD1 regulates critical cellular processes such as proliferation, differentiation, and migration during embryogenesis, tissue repair, and homeostasis. In bone biology, FZD1 mediates osteoblast differentiation and mineralization, promoting bone formation. Dysregulation of FZD1 has been linked to cancer, where it contributes to cell proliferation, survival, and metastasis, particularly in breast, lung, and colorectal cancers. Its overexpression enhances Wnt/β-catenin signaling, driving tumor progression and therapy resistance. FZD1 also regulates stem cell maintenance and epithelial-mesenchymal transition (EMT), processes critical for tissue regeneration and cancer metastasis. Additionally, its role in cardiac and renal development highlights its importance in organogenesis. Targeting FZD1 and its associated pathways is being explored in cancer therapy and regenerative medicine to modulate Wnt signaling and control disease progression.
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