Mouse Formyl Peptide Receptor 1 (FPR1) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Formyl Peptide Receptor 1 (FPR1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx389331
tested applications
ELISA
Description
Mouse Formyl Peptide Receptor 1 (FPR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse FPR1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Formyl Peptide Receptor 1 (FPR1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 46.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P33766 |
| Gene ID | 14293 |
| Alias | FPR1,NFPR,FPR,formyl peptide receptor 1,fMLF-R,FPR,FMLP |
| Background | Elisa kits for FPR1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
FPR1 is a G protein-coupled receptor (GPCR) expressed predominantly on immune cells, such as neutrophils and macrophages, where it mediates chemotaxis and host defense responses. It recognizes formylated peptides derived from bacterial and mitochondrial proteins, triggering immune cell recruitment to infection or damaged tissues. FPR1 activation stimulates downstream signaling pathways, including PI3K/Akt, MAPK, and calcium mobilization, leading to cellular migration, degranulation, and reactive oxygen species (ROS) production. It plays a critical role in the innate immune system by detecting bacterial infections and sterile inflammation. Dysregulation of FPR1 signaling contributes to chronic inflammatory diseases, autoimmune disorders, and impaired immune responses. In cancer, FPR1 expression has been associated with tumor progression and metastasis, where it can enhance cell migration and immune evasion. FPR1 also influences tissue repair and wound healing by directing immune cells to sites of injury. Its role in immune surveillance, inflammation, and cancer progression makes it an important target for therapies aimed at modulating immune responses and improving host defense mechanisms.
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