Mouse Fibroblast Growth Factor Receptor Like 1 (FGFRL1) ELISA Kit
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Description
Mouse Fibroblast Growth Factor Receptor Like 1 (FGFRL1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse FGFRL1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Fibroblast Growth Factor Receptor Like 1 (FGFRL1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q91V87 |
| Gene ID | 116701 |
| Alias | FHFR,FGFR5,FGFR-5,Fibroblast growth factor receptor 5,FGFR-like protein,FGF homologous factor receptor,FGF receptor-like protein 1 |
| Background | Elisa kits for FGFRL1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Fibroblast growth factor receptor like 1 (FGFRL1) FGFRL1 is a unique member of the FGFR family that lacks the intracellular tyrosine kinase domain, distinguishing it from other FGFRs. FGFRL1 contains an extracellular ligand-binding domain similar to other FGFRs, capable of binding FGFs and interacting with heparan sulfate proteoglycans. However, instead of activating intracellular signaling cascades, FGFRL1 is thought to act as a decoy receptor, modulating FGF availability and signaling. FGFRL1 plays a role in skeletal development, cartilage formation, and kidney morphogenesis, as evidenced by its high expression in these tissues during development. Mutations or dysregulation of FGFRL1 have been linked to skeletal abnormalities, including craniosynostosis and cartilage defects. Additionally, FGFRL1 may influence cellular adhesion and migration through interactions with extracellular matrix components. Its distinctive lack of kinase activity highlights its role as a regulatory rather than a signaling receptor in FGF-mediated processes.
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