Mouse Fibroblast Growth Factor Receptor 4 (FGFR4) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Mouse Fibroblast Growth Factor Receptor 4 (FGFR4) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx167430
Tested Applications
WB, SDS-PAGE
Description
Mouse Fibroblast Growth Factor Receptor 4 Protein is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Fibroblast Growth Factor Receptor 4 (FGFR4) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Val165-Asp366 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 26.2 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q03142 |
| Alias | TKF,JTK2,CD334,FGFR-4 |
| Background | Protein FGFR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Fibroblast growth factor receptor 4 (FGFR4) FGFR4 is a member of the fibroblast growth factor receptor (FGFR) family, characterized as a transmembrane tyrosine kinase receptor that binds FGFs to regulate cell proliferation, differentiation, migration, and survival. Structurally, FGFR4 consists of an extracellular ligand-binding domain composed of three immunoglobulin-like loops, a single transmembrane domain, and an intracellular tyrosine kinase domain. FGFR4 plays essential roles in embryonic development, metabolism, and tissue homeostasis, particularly in liver, muscle, and endocrine tissues. Ligand binding activates downstream signaling cascades, including the MAPK, PI3K-AKT, and STAT pathways, which are critical for cell growth and survival. Dysregulation of FGFR4 signaling has been implicated in various cancers, such as hepatocellular carcinoma and rhabdomyosarcoma, where overexpression or mutation drives tumor growth and metastasis. Its selective expression in specific tissues and its involvement in metabolic regulation, including bile acid synthesis, highlight its specialized biological functions and potential as a therapeutic target in oncology and metabolic disorders.
Productos relacionados
Fibroblast Growth Factor Receptor 4 (FGFR4) Antibody
FGFR4 Antibody is a Rabbit Polyclonal Antibody against FGFR4.…
Ver producto
Fibroblast Growth Factor Receptor 4 (FGFR4) Antibody
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence …
Ver producto
FGFR4 (Phospho-Tyr642) Antibody
Rabbit polyclonal antibody against FGFR4 protein. Immunogen region is C-terminal. Specificity is as follows for the reac…
Ver producto