Mouse FAS-Associated Death Domain Protein (FADD) ELISA Kit

Este producto es parte de FADD - FAS-associated death domain protein
Mouse FAS-Associated Death Domain Protein (FADD) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for FADD

proveedor

Abbexa

reference

abx389250

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse FAS-Associated Death Domain Protein (FADD) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse FAS-Associated Death Domain Protein (FADD) concentrations in serum, plasma and other biological fluids.

Background

FADD is an adaptor protein critical for death receptor-mediated apoptosis and immune signaling. It binds to death receptors like FAS (CD95), TNFR1, and TRAIL-R through its death domain (DD), facilitating the recruitment of caspase-8 to form the death-inducing signaling complex (DISC). This activates caspase cascades, leading to programmed cell death. FADD also participates in necroptosis, a caspase-independent cell death pathway, by interacting with receptor-interacting proteins (RIPK1 and RIPK3). Beyond cell death, FADD regulates T-cell proliferation, innate immune signaling, and NF-κB activation. Dysregulation of FADD is implicated in cancers, autoimmune diseases, and viral infections, where it affects apoptosis resistance and inflammation. Knockout studies reveal its essential role in embryonic development, immune homeostasis, and T-cell activation, emphasizing its dual function in cell survival and death signaling.

Características del producto

category

ELISA Kits

immunogen target

FAS-Associated Death Domain Protein (FADD)

reactivity

Mouse

test range

78 pg/ml - 5000 pg/ml

sensitivity

< 46.9 pg/ml

assay type

Sandwich

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Serum, plasma and other biological fluids.

size 1

96 tests

alias

FADD,GIG3, MORT1,IMD90

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

FADD

dry ice

No

uniprot id

https://www.uniprot.org/uniprotkb/Q61160

gene id

https://www.ncbi.nlm.nih.gov/gene/14082

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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