Mouse Estrogen Receptor Alpha (ESR1) Protein

Este producto es parte de ESR - estrogen receptor
Mouse Estrogen Receptor Alpha (ESR1) Protein
234€ (10 µg)

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Name
Mouse Estrogen Receptor Alpha (ESR1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx167364
Tested Applications
WB, SDS-PAGE

Description

Mouse Estrogen Receptor Alpha Protein is a recombinant Mouse protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Estrogen Receptor Alpha (ESR1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Ile233-Leu483
Tag: N-terminal His tag and GST tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 58.6 kDa  Observed MW (SDS-PAGE): 59 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P19785
Alias
ER,ESR,Era; ESRA,ESTRR,NR3A1,Nuclear receptor subfamily 3 group A member 1,Estradiol receptor
Background
Protein ESR1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

Estrogen receptor 1 (ESR1), also known as ERα, is a nuclear receptor that mediates the effects of estrogen, a key hormone in regulating the female reproductive system and other physiological processes ESR1 is expressed in a variety of tissues, including the breast, uterus, brain, and bones, where it regulates gene expression related to reproductive health, bone metabolism, and brain function Upon binding to estrogen, ESR1 undergoes a conformational change, allowing it to bind to estrogen response elements (EREs) on target genes and modulate their expression This activation regulates processes such as cell proliferation, differentiation, and apoptosis, and it is essential for the normal development of the reproductive organs and the maintenance of bone density Dysregulation of ESR1 has been linked to various diseases, particularly hormone receptor-positive breast cancer, where overactivation of ESR1 signaling promotes tumor cell growth and survival ESR1 is also a therapeutic target in breast cancer, with drugs like selective estrogen receptor modulators (SERMs) used to block or modulate its activity in cancer treatment

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