Mouse Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) ELISA Kit
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935106861
info@markelab.com
Precio
618.75€ (96 tests)
Elisa Kits DDR1
proveedor
Abbexareference
abx556080Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids
Background
Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase (RTK) that uniquely binds to collagens, distinguishing it from other RTKs that are primarily activated by growth factors or hormones. DDR1 is encoded by the DDR1 gene located on chromosome 6p21.3 in humans and is widely expressed across various tissues, including the kidneys, brain, lungs, and reproductive organs. DDR1 has critical roles in cell adhesion, proliferation, migration, and differentiation, primarily through its unique capacity to interact with the extracellular matrix (ECM), particularly collagens. As a collagen-binding receptor, DDR1 is involved in cellular responses to structural changes in the ECM, making it essential in tissue remodeling, wound healing, and organ development. DDR1 has become increasingly significant in the context of cancer biology due to its involvement in cell adhesion and motility, which are critical for metastasis. It is also implicated in fibrotic diseases, where it contributes to tissue stiffness and fibrosis, and in immune response modulation. The discovery of DDR1 has broadened the understanding of RTKs, as it revealed a subset of kinases that function primarily through interactions with ECM proteins, underscoring its role in both physiological and pathological conditions.
Características del producto
category
ELISA Kits
immunogen target
Epithelial Discoidin Domain-Containing Receptor 1 (DDR1)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.07 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
Epithelial discoidin domain-containing receptor 1,Epithelial discoidin domain receptor 1,CA, DDR,NEP,HGK2,PTK3,RTK6,TRKE,CD167,EDDR1,MCK10,NTRK4,PTK3A,Discoidin receptor tyrosine kinase,Mammary carcinoma kinase 10
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
DDR1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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