Mouse Endoglin / CD105 (ENG) Protein
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935106861
info@markelab.com
Precio
2301€ (1 mg)
Protein ENG
proveedor
Abbexareference
abx066402Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse Endoglin / CD105 (ENG) Protein is a Recombinant Protein produced in E.coli using Prokaryotic expression.
Background
Endoglin, encoded by the ENG gene, is a key transmembrane glycoprotein in the TGF-β (transforming growth factor-beta) receptor complex, with significant roles in vascular development and endothelial cell biology. Also known as CD105, endoglin is crucial in angiogenesis and vascular homeostasis. It is prominently expressed on the surface of endothelial cells, especially in active angiogenic areas, as well as in other cell types like smooth muscle cells and some immune cells. Endoglin regulates cellular responses to TGF-β signaling, particularly within endothelial cells, which is essential for their proliferation, migration, and survival. Mutations in the ENG gene are linked to hereditary hemorrhagic telangiectasia type 1 (HHT1), a genetic disorder characterized by abnormal blood vessel formation, causing arteriovenous malformations, frequent nosebleeds, and other bleeding-related symptoms. Endoglin also plays a prominent role in cancer biology, where it can act as a biomarker for tumor angiogenesis. Its dual role in promoting normal vascular health and contributing to disease makes it an essential molecule in vascular biology research.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Endoglin / CD105 (ENG)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Molecular Weight: Calculated MW: 13.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu27-Thr137 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ENG
dry ice
No
availability
Shipped within 1-2 months.
alias
END,HHT1,ORW1,CD105
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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