Mouse E3 Ubiquitin-Protein Ligase CBL (CBL) ELISA Kit

Este producto es parte de CBL - E3 ubiquitin protein ligase
Mouse E3 Ubiquitin-Protein Ligase CBL (CBL) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for CBL

proveedor

Abbexa

reference

abx388784

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse E3 Ubiquitin-Protein Ligase CBL (CBL) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse CBL concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

CBL is an E3 ubiquitin ligase that plays a crucial role in regulating signal transduction pathways, particularly those associated with receptor tyrosine kinases (RTKs) like the epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR). CBL mediates the ubiquitination of target proteins, leading to their degradation via the proteasome, and regulates the receptor's internalization and downregulation. This process ensures the proper termination of signaling, which is important for cellular processes such as growth, differentiation, and survival. Dysregulation of CBL activity has been implicated in various cancers, as uncontrolled signaling due to deficient ubiquitination can result in unchecked cell proliferation and survival.

Características del producto

category

ELISA Kits


immunogen target

E3 Ubiquitin-Protein Ligase CBL (CBL)


reactivity

Mouse


test range

0.78 ng/ml - 50 ng/ml


sensitivity

< 0.38 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

CBL, C-CBL2, FRA11B, NSLL, RNF55


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

CBL


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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