Mouse Docking protein 2 (Dok2) ELISA Kit

Este producto es parte de DOK - Docking protein
Mouse Docking protein 2 (Dok2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for DOK2

proveedor

Abbexa

reference

abx556046

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Docking protein 2 (Dok2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse DOK2 concentrations in serum, plasma and other biological fluids.


Background

Docking protein 2 (DOK2) is another member of the DOK family, predominantly expressed in hematopoietic cells. Like DOK1, DOK2 functions as a negative regulator of tyrosine kinase-mediated signaling pathways. It is essential for modulating immune cell activation, particularly in T cells, B cells, and macrophages. DOK2 interacts with various signaling proteins, such as SH2-containing phosphatase 2 (SHP2) and Ras-GAP, to dampen downstream signaling cascades. This regulation is vital for maintaining immune homeostasis and preventing overactivation that could lead to autoimmunity. DOK2 has also been identified as a tumor suppressor, with its inactivation or downregulation contributing to the pathogenesis of leukemias and other cancers. Its roles in both immune regulation and oncogenesis make it a key target for therapeutic research.

Características del producto

category

ELISA Kits


immunogen target

Docking protein 2 (Dok2)


reactivity

Mouse


test range

0.156 ng/ml - 10 ng/ml


sensitivity

0.078 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Serum, plasma and other biological fluids.


size 1

96 tests


alias

Downstream of tyrosine kinase 2,p56DOK,p56dok-2


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

DOK2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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