Mouse Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) ELISA Kit

Product specifications

ELISA Kits

Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)

Mouse

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

O35674

11492

MLTNB, MADDAM,Meltrin Beta,FKSG34,adam-19

Elisa kits for ADAM19

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ADAM19, or ADAM metallopeptidase domain 19, is a member of the ADAM (a disintegrin and metalloproteinase) family of proteins. These proteins are characterized by their multidomain structure, which includes a metalloproteinase domain responsible for enzymatic activity, a disintegrin domain involved in cell adhesion, and other functional domains such as cysteine-rich and EGF-like domain. ADAM19 is involved in various cellular processes, including cell adhesion, migration, and proteolysis. It has been implicated in the regulation of cell-cell and cell-matrix interactions, as well as in the proteolytic processing of membrane-bound proteins. The exact substrates and biological functions of ADAM19 are still being elucidated, but it is thought to play roles in development, tissue remodeling, and possibly in diseases. ADAM19 has been studied in the context of development, particularly in the central nervous system (CNS). It is expressed in regions of the brain and spinal cord during embryonic development, suggesting potential roles in neural development and circuit formation. Studies in animal models have shown that ADAM19 knockout mice exhibit abnormalities in neural tube closure, indicating its importance in early embryonic development.While the specific roles of ADAM19 in disease pathogenesis are not fully understood, alterations in its expression and activity have been reported in various pathological conditions. Dysregulation of ADAM19 has been observed in cancer, where it may contribute to tumor progression and metastasis by affecting cell adhesion and migration. Additionally, ADAM19 expression has been associated with certain cardiovascular diseases and inflammatory disorders, although further research is needed to fully elucidate its contributions to these conditions.

Related Products

anti- ADAM19 antibody

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone(By similarity).

Ver Producto

ADAM Metallopeptidase Domain 19 (ADAM19) Antibody

Rabbit Polyclonal against the ADAM19 protein.

Ver Producto

ADAM Metallopeptidase Domain 19 (ADAM19) Antibody

Rabbit Polyclonal against the ADAM19 protein.

Ver Producto