Mouse DENN domain-containing protein 1A (DENND1A) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DENND1A
proveedor
Abbexareference
abx510089Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse DENN domain-containing protein 1A (DENND1A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse DENN domain-containing protein 1A concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
DENN domain containing 1A (DENND1A) is a critical guanine nucleotide exchange factor (GEF) for Rab35, a small GTPase involved in endosomal trafficking and membrane recycling. DENND1A regulates the cycling of Rab35 between its GDP-bound inactive form and GTP-bound active state, promoting endosomal sorting and exocytosis. It is particularly important in processes like cytokinesis, where Rab35 facilitates the trafficking of vesicles required for the separation of daughter cells. DENND1A is also implicated in recycling plasma membrane components, such as receptors and transporters, ensuring proper cellular signaling and nutrient uptake. Dysregulation of DENND1A has been linked to pathological conditions, including polycystic ovary syndrome (PCOS), where it may contribute to hormonal imbalances and altered cellular signaling. Its tissue-specific expression, particularly in reproductive and endocrine tissues, underscores its specialized roles in vesicle trafficking and cellular function.
Características del producto
category
ELISA Kits
immunogen target
DENN domain-containing protein 1A (DENND1A)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
FAM31A,KIAA1608,Connecdenn 1,Connecdenn
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DENND1A
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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proveedor
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