Mouse Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Protein

Este producto es parte de CTLA4 - cytotoxic T-lymphocyte associated protein 4
Mouse Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein CTLA4

proveedor

Abbexa

reference

abx066270

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

Cytotoxic T-lymphocyte associated protein 4 (CTLA-4), encoded by the CTLA4 gene on chromosome 2, is an essential immune checkpoint receptor primarily expressed on activated T cells and regulatory T cells (Tregs). CTLA-4 plays a crucial role in maintaining immune homeostasis by delivering inhibitory signals to downregulate T cell activation and proliferation. This receptor functions by binding to the ligands CD80 (B7-1) and CD86 (B7-2), which are expressed on antigen-presenting cells (APCs). By inhibiting excessive immune responses, CTLA-4 prevents autoimmunity and maintains immune tolerance to self-antigens. CTLA-4 is the first immune checkpoint to have been targeted for immunotherapy, exemplified by the development of the monoclonal antibody ipilimumab, which blocks CTLA-4 to boost anti-tumor immune responses. Given its significance in regulating immune responses, CTLA-4 is a focus of research in fields ranging from oncology to autoimmune disorders.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 19.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val45-Ser185 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

CTLA4


dry ice

No


availability

Shipped within 5-7 working days.


alias

Cytotoxic T-lymphocyte protein 4,CD,GSE,GRD4,ALPS5,CD152,Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4,IDDM12,CELIAC3,


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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