Mouse Complement Decay-Accelerating Factor (CD55) Protein
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse Complement Decay-Accelerating Factor (CD55) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692439
tested applications
SDS-PAGE
Description
Mouse CD55 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mature form of mouse CD55 (Q61475) (Met 1-Thr 361) was expressed, with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD55 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 37.2 kDa Sequence Fragment: Met1-Thr361 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q61475 |
| Alias | Cromer blood group,CR,TC,DAF,CROM,CHAPLE,Complement decay-accelerating factor |
| Background | Protein CD55 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD55, also known as decay-accelerating factor (DAF), is a glycoprotein that plays a critical role in regulating the complement system, a part of the innate immune response. The primary function of CD55 is to protect host cells from complement-mediated damage by inhibiting the formation of C3 and C5 convertases, key enzymes in the complement activation pathways. CD55 is widely expressed on the surface of many cell types, including erythrocytes, leukocytes, endothelial cells, and epithelial cells. Its expression is essential for preventing unintended complement activation on host tissues, which could lead to cell lysis and tissue damage. CD55 is particularly important in safeguarding cells from the alternative pathway and classical pathway of complement activation. The complement system is a major defense mechanism that helps the body clear pathogens through opsonization, inflammation, and lysis of infected or foreign cells. By regulating this system, CD55 ensures that the complement system does not damage self-cells, thus maintaining tissue integrity during immune responses.
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This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins.
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