Mouse Cholinergic Receptor, Muscarinic 2 (CHRM2) CLIA Kit
845€ (96 tests)
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935106861
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name
Mouse Cholinergic Receptor, Muscarinic 2 (CHRM2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx492495
tested applications
CLIA
Description
Mouse Cholinergic Receptor, Muscarinic 2 (CHRM2) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Cholinergic Receptor, Muscarinic 2 (CHRM2) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.054 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CHRM2 ,M2 muscarinic acetylcholine receptor,AChR M2,Chrm-2,cholinergic receptor muscarinic 2,cholinergic receptor,cholinergic receptor, muscarinic 2, cardiac,M2 receptor,HM2 |
| Background | CLIA Kits CHRM2 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CHRM2 encodes the cholinergic receptor muscarinic 2, which is another member of the G protein-coupled receptor family and primarily couples to Gi/o proteins. Activation of CHRM2 leads to inhibition of adenylate cyclase, thereby reducing intracellular cyclic AMP (cAMP) levels and leading to decreased cellular excitability. CHRM2 is expressed in the heart, brainstem, and vagus nerve, where it plays a key role in modulating cardiovascular function and parasympathetic nervous system activity. In the heart, CHRM2 activation slows heart rate by reducing the firing rate of sinoatrial (SA) node cells, a mechanism vital for maintaining resting heart rate and promoting vagal tone. In the brain, CHRM2 is implicated in processes related to cognition, mood regulation, and stress response, making it relevant for disorders such as depression and anxiety. Genetic variations in CHRM2 have been associated with cognitive performance and psychiatric conditions, including alcohol dependence. Pharmacologically, CHRM2 antagonists are used in cardiac treatment to counteract excessive parasympathetic activity, while selective agonists may have potential therapeutic applications in improving memory function and treating mood disorders.
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