Mouse Cell Adhesion Molecule 4 (CADM4) Protein

Este producto es parte de CADM - cell adhesion molecule
Product Graph
1079€ (100 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Mouse Cell Adhesion Molecule 4 (CADM4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692152
tested applications
SDS-PAGE

Description

Mouse CADM4 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of mouse CADM4 (NP_694752.1) (Met 1-Ala 324) was expressed, with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
CADM4
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: 34.5 kDa
Sequence Fragment: Met1-Ala324
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 97% (SDS-PAGE)
Size 1
100 µg
Form
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_694752.1
Alias
NECL4,TSLL2,IGSF4C,Necl-4,synCAM4,TSLC1-like protein 2,Nectin-like protein 4,Immunoglobulin superfamily member 4C
Background
Protein CADM4
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CADM4, also known as SynCAM4 or nectin-like molecule 4 (Necl-4), is a member of the immunoglobulin superfamily and plays a critical role in cell-cell adhesion, particularly in epithelial and nervous tissues. It mediates both homophilic and heterophilic interactions, contributing to cellular polarity, tight junction formation, and signal transduction. CADM4 is expressed in a wide range of tissues, including the prostate, brain, and skin, where it is involved in maintaining epithelial integrity and regulating cell proliferation. Dysregulation of CADM4 is associated with tumorigenesis, as its downregulation has been observed in various cancers, including lung, prostate, and bladder cancers, suggesting its role as a tumor suppressor. It interacts with intracellular scaffolding proteins and cytoskeletal regulators, enabling its involvement in signaling pathways that influence cell migration and invasion. CADM4's extracellular domains mediate adhesion, while its intracellular domains anchor to cytoskeletal components, reinforcing its structural and signaling roles. Emerging research indicates that CADM4 may also influence immune responses and neuronal synaptic organization, highlighting its diverse functional significance.
Related Products
FNab01192
anti- CADM4 antibody
Involved in the cell-cell adhesion. Has calcium-and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.
Ver Producto
abx013926
Cell Adhesion Molecule 4 (CADM4) Antibody
Rabbit polyclonal antibody against CADM4 protein. Immunogen region is C-terminal.
Ver Producto
abx214091
Cell Adhesion Molecule 4 (CADM4) Antibody
CADM4 Antibody is a Rabbit Polyclonal against CADM4.
Ver Producto