Mouse Cell Adhesion Molecule 4 (CADM4) Protein
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse Cell Adhesion Molecule 4 (CADM4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692152
tested applications
SDS-PAGE
Description
Mouse CADM4 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of mouse CADM4 (NP_694752.1) (Met 1-Ala 324) was expressed, with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CADM4 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 34.5 kDa Sequence Fragment: Met1-Ala324 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_694752.1 |
| Alias | NECL4,TSLL2,IGSF4C,Necl-4,synCAM4,TSLC1-like protein 2,Nectin-like protein 4,Immunoglobulin superfamily member 4C |
| Background | Protein CADM4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CADM4, also known as SynCAM4 or nectin-like molecule 4 (Necl-4), is a member of the immunoglobulin superfamily and plays a critical role in cell-cell adhesion, particularly in epithelial and nervous tissues. It mediates both homophilic and heterophilic interactions, contributing to cellular polarity, tight junction formation, and signal transduction. CADM4 is expressed in a wide range of tissues, including the prostate, brain, and skin, where it is involved in maintaining epithelial integrity and regulating cell proliferation. Dysregulation of CADM4 is associated with tumorigenesis, as its downregulation has been observed in various cancers, including lung, prostate, and bladder cancers, suggesting its role as a tumor suppressor. It interacts with intracellular scaffolding proteins and cytoskeletal regulators, enabling its involvement in signaling pathways that influence cell migration and invasion. CADM4's extracellular domains mediate adhesion, while its intracellular domains anchor to cytoskeletal components, reinforcing its structural and signaling roles. Emerging research indicates that CADM4 may also influence immune responses and neuronal synaptic organization, highlighting its diverse functional significance.
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