Mouse Cell Adhesion Molecule 1 (CADM1) Protein
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Description
Mouse CADM1 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse CADM1 (NP_061240.3) (Met1-His377) was expressed with a polyhistidine tag at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cell Adhesion Molecule 1 (CADM1) |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 38.5 kDa Sequence Fragment: Met1-His377 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BY67 |
| Gene ID | 23705 |
| NCBI Accession | NP_061240.3 |
| OMIM | 605686 |
| Alias | BL2,ST17,IGSF4,NECL2,RA175,TSLC1,IGSF4A,Necl-2,SYNCAM,sgIGSF,sTSLC-1,synCAM1,Tumor suppressor in lung cancer 1,Nectin-like protein 2,Immunoglobulin superfamily member 4 |
| Background | Protein CADM1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CADM1, also known as synaptic cell adhesion molecule (SynCAM1), is a member of the immunoglobulin superfamily and plays a pivotal role in cell-cell adhesion, synapse formation, and immune cell interactions. It is widely expressed in the nervous system, epithelial tissues, and immune cells, mediating interactions between neurons, epithelial cells, and immune cells. CADM1 is involved in the establishment and maintenance of synaptic connections, particularly in excitatory synapses, and contributes to neuronal network stability and plasticity. It has tumor-suppressive properties, with reduced expression frequently observed in cancers such as lung adenocarcinoma, where it is associated with increased invasiveness and metastasis. CADM1 interacts with scaffolding proteins and cytoskeletal regulators, facilitating intracellular signaling pathways that regulate cell polarity, migration, and proliferation. Structural studies have identified its extracellular immunoglobulin-like domains as critical for homophilic and heterophilic interactions, enabling diverse adhesive functions. CADM1 also plays a role in the immune system by modulating mast cell adhesion and interaction with nerve fibers. Dysregulation of CADM1 has been linked to neurodevelopmental disorders and inflammatory diseases, underscoring its significance in both physiological and pathological processes.
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anti- CADM1 antibody
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer(NSCLC) cells. Interaction with CRTAM promotes natural killer(NK) cell cytotoxicity and interferon-gamma(IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly(By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
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anti- Cadm1 antibody
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer(NSCLC) cells. Interaction with CRTAM promotes natural killer(NK) cell cytotoxicity and interferon-gamma(IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Ver Producto
anti- CADM1 antibody
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer(NSCLC) cells. Interaction with CRTAM promotes natural killer(NK) cell cytotoxicity and interferon-gamma(IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly(By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
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