Mouse Calcitonin Receptor (CALCR) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Mouse Calcitonin Receptor (CALCR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168954
tested applications
WB, SDS-PAGE
Description
Mouse Calcitonin Receptor (CALCR) Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Calcitonin Receptor (CALCR) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 18.8 kDa Observed MW (SDS-PAGE): 19 kDa Concentration: Prior to lyophilization: 1200 µg/ml Sequence Fragment: Ala42-Leu170 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q60755 |
| Alias | CRT, CT-R, CTR, CTR1 |
| Background | Protein CALCR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Calcitonin Receptor (CALCR) is a G-protein-coupled receptor that mediates the actions of calcitonin, a hormone primarily involved in calcium homeostasis and bone metabolism. CALCR is predominantly expressed in osteoclasts, where it inhibits bone resorption by reducing osteoclast activity and survival, thus maintaining bone mineral density. This function is critical for conditions like osteoporosis, where dysregulated bone turnover leads to bone fragility. Beyond bone health, CALCR is also expressed in the kidneys, where it enhances renal calcium excretion to regulate systemic calcium levels. Additionally, CALCR signaling in the central nervous system influences appetite regulation and energy metabolism, providing potential roles in managing obesity and metabolic disorders. CALCR is activated not only by calcitonin but also by related peptides, such as amylin, which are involved in glucose homeostasis and insulin secretion. Importantly, CALCR has been implicated in cancer progression, particularly in bone metastasis, where calcitonin receptor expression correlates with increased osteoclast activity and skeletal degradation. Dysregulation of CALCR signaling is also associated with diseases like Paget's disease and hypercalcemia of malignancy, where excessive calcium release disrupts homeostasis. Therapeutically, calcitonin analogs and CALCR-targeted drugs are widely used for treating osteoporosis, hypercalcemia, and bone pain. Emerging research suggests that CALCR may have broader roles in cardiovascular and neurodegenerative conditions, further underscoring its biological versatility and therapeutic potential.
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