Mouse Calcitonin Gene Related Peptide Type 1 Receptor (CALCRL) ELISA Kit

Este producto es parte de CALCR - Calcitonin Receptor (Like)
Product Graph
715€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Mouse Calcitonin Gene Related Peptide Type 1 Receptor (CALCRL) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx556045
tested applications
ELISA

Description

Mouse Calcitonin Gene Related Peptide Type 1 Receptor (CALCRL) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Calcitonin Gene Related Peptide Type 1 Receptor (CALCRL) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

CategoryELISA Kits
Immunogen TargetCalcitonin Gene Related Peptide Type 1 Receptor (CALCRL)
ReactivityMouse
Detection MethodColorimetric
Assay DataQuantitative
Assay TypeSandwich
Test Range0.312 ng/ml - 20 ng/ml
Sensitivity0.156 ng/ml
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
Size 196 tests
FormLyophilized
Tested ApplicationsELISA
Sample TypeTissue homogenates, cell lysates and other biological fluids.
AvailabilityShipped within 1-3 weeks. The validity for this kit is 6 months.
StorageShipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry IceNo
UniProt IDQ9R1W5
AliasCRLR,CGRPR,LMPHM8
BackgroundElisa kits for CALCRL
StatusRUO
NoteValidity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Calcitonin Receptor-Like Receptor (CALCRL) is a member of the G-protein-coupled receptor (GPCR) family and plays a critical role in diverse physiological processes by interacting with Receptor Activity Modifying Proteins (RAMPs). Its function depends on the specific RAMP partner, leading to the formation of multiple receptor subtypes with distinct biological roles. When CALCRL associates with RAMP1, it forms the Calcitonin Gene-Related Peptide (CGRP) receptor, which regulates vasodilation, pain transmission, and neurogenic inflammation, especially in migraine pathophysiology. Conversely, when paired with RAMP2 or RAMP3, CALCRL becomes a receptor for adrenomedullin (AM) and adrenomedullin 2/intermedin, respectively. These signaling pathways are vital for maintaining vascular tone, endothelial barrier integrity, and angiogenesis, especially during conditions like sepsis, heart failure, and ischemic injuries. CALCRL expression is prominent in the cardiovascular system, kidneys, lungs, and central nervous system, making it a critical target for therapeutic interventions in vascular diseases and inflammatory conditions. Dysregulation of CALCRL is implicated in pathological states, such as pulmonary hypertension, cardiac hypertrophy, and cancer progression, where it promotes tumor angiogenesis and metastasis. Given its widespread biological importance, CALCRL is being actively studied as a therapeutic target, with antagonists and modulators showing promise for treating migraines, hypertension, and cardiovascular disorders. Additionally, its role in fluid regulation and immune responses highlights its systemic relevance across various organs.

Related Products

EH4194

Human CALCRL(calcitonin receptor-like receptor) ELISA Kit

Ver Producto
FNab09879

anti- CALCRL antibody

Ver Producto
abx029840

Calcitonin Gene-Related Peptide Type 1 Receptor (CALCRL) Antibody

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Ver Producto