Mouse Cadherin, Neuronal (CDH2) Protein

Product specifications

Proteins and Peptides

Cadherin, Neuronal (CDH2)

E. coli

Mouse

Unconjugated

Molecular Weight: Calculated MW: 21.3 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ala384-Glu562
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-12 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P15116

Cadherin-2,CDHN,NCAD,ACOGS,ADHD8,CD325,ARVD14,CDw325,Neural cadherin,N-cadherin

Protein CDH2

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Cadherin 2 (CDH2), also known as N-cadherin (neural cadherin), is a calcium-dependent cell adhesion molecule that belongs to the classical cadherin family. This protein is primarily expressed in neural tissue, muscle, and endothelial cells, facilitating cell-cell adhesion that is crucial for the organization and stability of various tissues, particularly during development. CDH2 mediates homophilic cell adhesion by binding to other N-cadherin molecules on neighboring cells, helping establish stable cellular contacts necessary for tissue integrity and function. Unlike CDH1, which is primarily expressed in epithelial cells, CDH2 is prevalent in mesenchymal and neural cell types and is integral to processes like embryogenesis, neural development, and wound healing. N-cadherin’s role extends beyond basic cell adhesion, as it is actively involved in signaling pathways that regulate cell migration, differentiation, and survival. In particular, CDH2 is essential during the development of the nervous system, heart, and vasculature, contributing to the morphogenesis of organs and the maintenance of neuronal connections. Additionally, CDH2 expression has significant implications in cancer progression and metastasis, particularly through the process of epithelial-mesenchymal transition (EMT), where it replaces CDH1 as cells transition to a more migratory, invasive phenotype. This behavior makes CDH2 a critical molecule not only in normal development but also in disease progression.

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