Mouse C-C Chemokine Receptor Type 2 (CCR2) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
Mouse C-C Chemokine Receptor Type 2 (CCR2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx492221
tested applications
CLIA
Description
Mouse C-C Chemokine Receptor Type 2 (CCR2) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | C-C Chemokine Receptor Type 2 (CCR2) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78.12 pg/ml - 5000 pg/ml |
| Sensitivity | < 34 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CCR2,MCP-1 receptor,CC CKR2,CKR2,CD192,CCR2A,CCR2B,chemokine receptor CCR2,chemokine (C-C motif) receptor 2,CCR-2,CKR2A,CKR2B,CMKBR2,MCP-1-R,CC-CKR-2 |
| Background | CLIA Kits CCR2 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
C-C Chemokine Receptor Type 2 (CCR2) is a critical G-protein-coupled receptor (GPCR) that binds C-C chemokines, primarily CCL2 (MCP-1) and related ligands such as CCL7 and CCL8. CCR2 is expressed on monocytes, macrophages, T cells, and dendritic cells, playing a central role in monocyte recruitment to sites of inflammation and tissue damage. Upon binding its ligands, CCR2 triggers intracellular signaling pathways such as MAPK, JAK/STAT, and PI3K, leading to cell activation, chemotaxis, and cytokine production. CCR2 and its ligand CCL2 are vital in the immune response to infections, promoting pathogen clearance, but their dysregulation is implicated in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, obesity, and chronic kidney disease. In cancer, CCR2 contributes to tumor progression by recruiting tumor-associated macrophages (TAMs), which promote angiogenesis, immune suppression, and metastasis. Targeting CCR2 has emerged as a promising strategy for modulating inflammatory responses and treating cancers, with CCR2 antagonists in development for conditions like fibrosis, autoimmunity, and tumor microenvironment modulation. Research into CCR2 signaling continues to elucidate its role in monocyte biology, chronic inflammation, and immune regulation, positioning it as a key therapeutic target for inflammatory diseases and cancer therapies.
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