Mouse Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Mouse Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q09324 |
| Gene ID | 14537 |
| Alias | G6NT,C2GNT,C2GNT1,NACGT2,NAGCT2,C2GNT-L,C2GlcNAcT |
| Background | Elisa kits for GCNT1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Glucosaminyl (N-acetyl) transferase 1 (GCNT1) is a glycosyltransferase that catalyzes the addition of N-acetylglucosamine to mucin-type O-glycans, forming core 2 and core 4 branched structures critical for glycoprotein biosynthesis GCNT1 plays a key role in the synthesis of mucins, which protect epithelial barriers in the gastrointestinal and respiratory tracts by regulating mucus production and cell adhesion It is expressed in various tissues, particularly those with high mucus turnover, and is vital for immune responses and cellular signaling Dysregulation of GCNT1 has been associated with cancer progression, especially in breast and gastrointestinal cancers, where aberrant glycosylation promotes tumor invasion and metastasis Additionally, GCNT1 contributes to inflammatory diseases, impacting immune cell trafficking and epithelial defense pathways Studies highlight its involvement in maintaining epithelial integrity and its therapeutic potential as a target for diseases characterized by disrupted glycosylation patterns
Related Products
Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase (GCNT1) Antibody
This gene is a member of the beta-1, 6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3 (GlcNAc beta 1-6) GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Ver Producto
Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase (GCNT1) Antibody
Glycosylation is one of the most universal but at the same time complex protein modifications. Modification with sugar moeties can be both co translational and post translational, occurring in the endoplasmatic reticulum and golgi. Three different forms of glycosylation can be distinguished: N-linked oligosaccharides, O-linked oligosaccharides and glycosyl phosphatidylinositol (GPI-) anchors. Glycosylation results in thousands of distinct, bioactive glycoproteins resident throughout the cell that strongly determine protein-protein, carbohydrate-protein, membrane, and adhesion properties. Diseases associated with glycosylation defects include Congenital disorders of glycosylation, (CDG), also known as carbohydrate deficient glycoprotein syndromes, and diseases associated with advanced aging.
Ver Producto
Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase (GCNT1) Antibody
Glycosylation is one of the most universal but at the same time complex protein modifications. Modification with sugar moeties can be both co translational and post translational, occurring in the endoplasmatic reticulum and golgi. Three different forms of glycosylation can be distinguished: N-linked oligosaccharides, O-linked oligosaccharides and glycosyl phosphatidylinositol (GPI-) anchors. Glycosylation results in thousands of distinct, bioactive glycoproteins resident throughout the cell that strongly determine protein-protein, carbohydrate-protein, membrane, and adhesion properties. Diseases associated with glycosylation defects include Congenital disorders of glycosylation, (CDG), also known as carbohydrate deficient glycoprotein syndromes, and diseases associated with advanced aging.
Ver Producto