Mouse BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit

Este producto es parte de BAK1 - BCL2 antagonist/killer 1
Mouse BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

578.5€ (96 tests)

Elisa kits for BAK1

proveedor

Abbexa

reference

abx352515

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse BCL2 Antagonist/Killer 1 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

BCL2 antagonist/killer 1 (BAK1) is a pro-apoptotic member of the Bcl-2 family of proteins, which regulate cell death pathways and cellular survival BAK1 plays a critical role in mitochondrial-mediated apoptosis, where it promotes the release of cytochrome c from the mitochondria, triggering the activation of caspase enzymes that lead to programmed cell death It functions as a key mediator of apoptosis in response to cellular stress, DNA damage, and oncogenic signaling, making it essential for maintaining cellular homeostasis and preventing the accumulation of damaged cells BAK1's activation is tightly regulated by anti-apoptotic proteins like Bcl-2, and its dysregulation is commonly associated with cancer, where loss of BAK1 function allows tumor cells to evade apoptosis, promoting tumor growth and resistance to chemotherapy Studies have also linked BAK1 to neurodegenerative diseases, where its dysregulation may contribute to neuronal loss and dysfunction Additionally, BAK1 has been implicated in immune responses, where it regulates T-cell homeostasis and immune cell survival, underscoring its broader role in cellular death and immune regulation

Características del producto

category

ELISA Kits


immunogen target

BCL2 Antagonist/Killer 1 (BAK1)


reactivity

Mouse


test range

0.156 ng/ml - 10 ng/ml


sensitivity

0.1 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

BAK,BAK-LIKE,BCL2L7,CDN1,Bcl-2 homologous antagonist/killer,Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

BAK1


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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