Mouse BAG Family Molecular Chaperone Regulator 1 (BAG1) Protein
195€ (10 µg)
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Name
Mouse BAG Family Molecular Chaperone Regulator 1 (BAG1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx650938
Tested Applications
WB, SDS-PAGE
Description
Mouse BAG1 Protein is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | BAG1 |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gly174-Glu355 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 24.3 kDa Observed MW (SDS-PAGE): 24.3 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q60739 |
| Alias | HAP,BAG-1,RAP46,Bcl-2-associated athanogene 1,BAG family molecular chaperone regulator 1 |
| Background | Protein BAG1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
BAG cochaperone 1 (BAG1) is a cochaperone protein that interacts with heat shock proteins (HSPs) to regulate protein folding, degradation, and cellular stress responses BAG1 plays a critical role in modulating the activity of HSP70 and HSP90, chaperone proteins that assist in the proper folding and stabilization of client proteins It facilitates protein degradation by interacting with the E3 ubiquitin ligase system, ensuring the removal of misfolded or damaged proteins under cellular stress BAG1 is involved in cell survival, apoptosis, and the regulation of cell signaling, particularly in response to oxidative stress and other damaging conditions It also interacts with transcription factors and signaling molecules to influence gene expression and cellular differentiation BAG1 has been implicated in various cancers, where it promotes tumor cell survival and resistance to chemotherapy by stabilizing key oncogenic proteins Additionally, BAG1’s role in apoptosis regulation and cellular stress responses highlights its potential as a therapeutic target for diseases related to protein misfolding, cancer, and neurodegeneration