Mouse B-Cell Differentiation Antigen CD72 (CD72) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Mouse B-Cell Differentiation Antigen CD72 (CD72) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167294
tested applications
WB, SDS-PAGE
Description
Cluster Of Differentiation 72 Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | B-Cell Differentiation Antigen CD72 (CD72) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 27.9 kDa Observed MW (SDS-PAGE): 26 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu143-Phe345 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | LYB2,CD72b,B-cell differentiation antigen CD72 |
| Background | Protein CD72 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD72 is a type II transmembrane glycoprotein belonging to the C-type lectin superfamily. It is mainly expressed on the surface of B cells, as well as some other immune cells such as dendritic cells. CD72 serves as a negative regulator of B cell receptor (BCR) signaling, modulating immune responses by attenuating excessive B cell activation and preventing autoimmunity. CD72 interacts with protein tyrosine phosphatases, including SHP-1 and SHP-2, through its immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic domain. When activated, CD72 negatively regulates BCR signaling, contributing to the maintenance of immune tolerance and B cell homeostasis. Given its central role in B cell regulation, CD72 is involved in autoimmune diseases, chronic inflammatory conditions, and lymphomas.
