Mouse B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein BCL2L2
proveedor
Abbexareference
abx065507Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
BCL2 like 2 (BCL2L2), also known as BCL-W, is another anti-apoptotic protein in the Bcl-2 family, crucial for regulating cell survival by preventing mitochondrial apoptosis BCL2L2 interacts with pro-apoptotic proteins such as Bax and Bak, preventing their activation and the subsequent release of cytochrome c from the mitochondria BCL2L2’s role in inhibiting apoptosis is particularly important in cells that undergo high levels of stress, such as hematopoietic cells and certain neuronal populations Dysregulation of BCL2L2 has been associated with cancer, where its overexpression allows tumor cells to evade apoptosis, contributing to tumor survival, metastasis, and resistance to chemotherapy In addition, BCL2L2 is involved in maintaining tissue homeostasis and immune cell survival, influencing T-cell differentiation and activation Studies have suggested that BCL2L2 could be targeted for therapeutic purposes in both cancer and autoimmune diseases, where modulating cell death pathways can improve patient outcomes
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 19.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu22-Phe189 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
BCL2L2
dry ice
No
availability
Shipped within 5-12 working days.
alias
Bcl-2-like protein 2,BCLW,BCL-W,PPP1R51,BCL2-L-2,Apoptosis regulator Bcl-W
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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