Mouse Autoimmune Regulator (AIRE) CLIA Kit

Este producto es parte de AIRE - Autoimmune Regulator
Mouse Autoimmune Regulator (AIRE) CLIA Kit

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935106861

info@markelab.com

Precio

812.5€ (96 tests)

CLIA Kits AIRE

proveedor

Abbexa

reference

abx493616

Tested Applications

CLIA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Autoimmune Regulator (AIRE) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.


Mouse Autoimmune Regulator (AIRE) CLIA Kit es un kit CLIA tipo Sandwich para su uso con homogeizados de tejido y otros fluidos biológicos.


Background

The Autoimmune Regulator (AIRE) is a protein encoded by the AIRE gene, and it plays a critical role in immune tolerance and the prevention of autoimmune diseases. AIRE is primarily expressed in a specialized type of cell called medullary thymic epithelial cells (mTECs) found in the thymus gland. AIRE functions as a transcriptional regulator, controlling the expression of a wide range of tissue-specific antigens (TSAs) within mTECs. These TSAs represent proteins that are normally expressed in various tissues. By inducing the expression of TSAs in the thymus, AIRE ensures that developing T cells encounter a diverse array of self-antigens during their maturation process.The exposure of developing T cells to self-antigens in the thymus is crucial for their selection and education. T cells that recognize self-antigens too strongly or too weakly are eliminated or rendered tolerant, respectively, through a process known as central tolerance. AIRE-mediated expression of TSAs in mTECs is a key mechanism by which central tolerance is maintained, helping to prevent the development of autoimmune responses against self-tissues. Mutations in the AIRE gene lead to a rare autoimmune disorder known as autoimmune polyendocrine syndrome type 1 (APS-1), also called autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). APS-1 is characterized by the development of multiple autoimmune diseases affecting various endocrine organs, such as the adrenal glands, parathyroid glands, and pancreas, as well as other tissues. These autoimmune manifestations result from defects in central tolerance due to impaired AIRE function, leading to the escape of autoreactive T cells from thymic deletion.

Características del producto

category

CLIA Kits


immunogen target

Autoimmune Regulator (AIRE)


reactivity

Mouse


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.058 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Chemiluminescent


sample type

Tissue homogenates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

AIRE1,APECED,APS1,APSI,PGA1


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

AIRE


dry ice

No


note

El rango y la sensibilidad pueden variar. Le recomendamos contactar con nosotros a fin de obtener la última información sobre posibles actualizaciones, que no estén representadas en este catalogo. Si necesita un rango específico, contáctenos y trataremos de ayudarle. Consulte sobre posible información que pueda ayudarle a elegir la dilución apropiada para sus muestras. Los kits CLIA están optimizados para la detección de muestras nativas, las proteínas recombinantes, pueden resultar problemáticas a causa de diferencias en la secuencia o cambios en la estructura terciaria.


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