Mouse Autoimmune Regulator (AIRE) CLIA Kit
Pida mas información
935106861
info@markelab.com
Precio
812.5€ (96 tests)
CLIA Kits AIRE
proveedor
Abbexareference
abx493616Tested Applications
CLIAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Autoimmune Regulator (AIRE) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
Mouse Autoimmune Regulator (AIRE) CLIA Kit es un kit CLIA tipo Sandwich para su uso con homogeizados de tejido y otros fluidos biológicos.
Background
The Autoimmune Regulator (AIRE) is a protein encoded by the AIRE gene, and it plays a critical role in immune tolerance and the prevention of autoimmune diseases. AIRE is primarily expressed in a specialized type of cell called medullary thymic epithelial cells (mTECs) found in the thymus gland. AIRE functions as a transcriptional regulator, controlling the expression of a wide range of tissue-specific antigens (TSAs) within mTECs. These TSAs represent proteins that are normally expressed in various tissues. By inducing the expression of TSAs in the thymus, AIRE ensures that developing T cells encounter a diverse array of self-antigens during their maturation process.The exposure of developing T cells to self-antigens in the thymus is crucial for their selection and education. T cells that recognize self-antigens too strongly or too weakly are eliminated or rendered tolerant, respectively, through a process known as central tolerance. AIRE-mediated expression of TSAs in mTECs is a key mechanism by which central tolerance is maintained, helping to prevent the development of autoimmune responses against self-tissues. Mutations in the AIRE gene lead to a rare autoimmune disorder known as autoimmune polyendocrine syndrome type 1 (APS-1), also called autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). APS-1 is characterized by the development of multiple autoimmune diseases affecting various endocrine organs, such as the adrenal glands, parathyroid glands, and pancreas, as well as other tissues. These autoimmune manifestations result from defects in central tolerance due to impaired AIRE function, leading to the escape of autoreactive T cells from thymic deletion.
Características del producto
category
CLIA Kits
immunogen target
Autoimmune Regulator (AIRE)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.058 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Chemiluminescent
sample type
Tissue homogenates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
AIRE1,APECED,APS1,APSI,PGA1
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
AIRE
dry ice
No
note
El rango y la sensibilidad pueden variar. Le recomendamos contactar con nosotros a fin de obtener la última información sobre posibles actualizaciones, que no estén representadas en este catalogo. Si necesita un rango específico, contáctenos y trataremos de ayudarle. Consulte sobre posible información que pueda ayudarle a elegir la dilución apropiada para sus muestras. Los kits CLIA están optimizados para la detección de muestras nativas, las proteínas recombinantes, pueden resultar problemáticas a causa de diferencias en la secuencia o cambios en la estructura terciaria.
Quizá le pueda interesar
Human AIRE(Autoimmune regulator) ELISA Kit
proveedor
FineTestreference
EH1501reactivity
humanstatus
RUOPrecio a consultar
Ver másanti- AIRE antibody
proveedor
FineTestreference
FNab00241Tested Applications
ELISA, WB, IHCreactivity
human,mousestatus
RUOclonality
polyclonalTranscriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an...
Precio a consultar
Ver másAutoimmune Regulator (AIRE) Antibody
proveedor
Abbexareference
abx001466Tested Applications
WB, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalAIRE Antibody is a Rabbit Polyclonal antibody against AIRE. This gene encodes a transcriptional regulator that forms nuc...
175€ (20 µl)
Ver más