Mouse Aryl Hydrocarbon Receptor (AhR) Protein

247€ (10 µg)
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935106861
info@markelab.com
name
Mouse Aryl Hydrocarbon Receptor (AhR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167502
tested applications
WB, SDS-PAGE
Description
Aryl Hydrocarbon Receptor Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Aryl Hydrocarbon Receptor (AhR) |
Host | E. coli |
Origin | Mouse |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 59.5 kDa Observed MW (SDS-PAGE): 59 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val126-Gly385 Tag: N-terminal His tag and GST tag |
Expression | Recombinant |
Purity | > 95% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01%Sarcosyl, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | RP85,bHLHe76 |
Background | Protein AHR |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AHR is a ligand-activated transcription factor involved in sensing and responding to environmental toxins, such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Upon ligand binding, AHR translocates from the cytoplasm to the nucleus, where it forms a heterodimer with the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) and binds to DNA at xenobiotic response elements (XREs), regulating the expression of detoxification enzymes like CYP1A1 and CYP1B1. AHR is expressed in a variety of tissues, including the liver, skin, and immune system, and plays roles in xenobiotic metabolism, immune regulation, cell differentiation, and circadian rhythm modulation. Dysregulation of AHR activity is implicated in immune dysfunction, autoimmune diseases, and cancer, where it influences tumor progression and metastasis. AHR’s dual role in both normal homeostasis and pathological conditions makes it a target of interest in toxicology, immunology, and cancer research.
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