Mouse Aryl Hydrocarbon Interacting Protein Like 1 (AIPL1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for AIPL1
proveedor
Abbexareference
abx388615Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Aryl Hydrocarbon Interacting Protein Like 1 (AIPL1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse AIPL1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
AIPL1 is a specialized molecular chaperone predominantly expressed in retinal photoreceptor cells, where it plays a crucial role in the folding, stability, and assembly of proteins essential for phototransduction. Structurally, AIPL1 contains tetratricopeptide repeat (TPR) domains, which mediate protein-protein interactions, and a FKBP-like domain, enabling its chaperone activity. AIPL1 is critical for the proper function of phosphodiesterase 6 (PDE6), a key enzyme in the visual cycle. It helps stabilize PDE6 subunits during their assembly, ensuring efficient phototransduction signaling. Mutations in the AIPL1 gene are associated with severe retinal degenerative diseases, including Leber congenital amaurosis type 4 (LCA4) and retinitis pigmentosa (RP). These conditions result from impaired PDE6 function, leading to photoreceptor cell death and progressive vision loss. Due to its specific expression in photoreceptors and essential role in their survival, AIPL1 is a target of interest for gene therapy and retinal disease research.
Características del producto
category
ELISA Kits
immunogen target
Aryl Hydrocarbon Interacting Protein Like 1 (AIPL1)
reactivity
Mouse
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 46.9 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
AIPL2, LCA4
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
AIPL1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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