Mouse Arginine Vasopressin Receptor 1B (AVPR1B) Protein

Background

AVPR1B is a G protein-coupled receptor that binds the hormone arginine vasopressin (AVP), a key regulator of water balance, blood pressure, and social behaviors. This receptor is primarily expressed in the anterior pituitary, where it plays an important role in the secretion of ACTH (adrenocorticotropic hormone) in response to stress. AVPR1B also plays a role in regulating behaviors associated with the stress response, including anxiety and social interactions. Upon activation, AVPR1B couples to Gq proteins, stimulating phospholipase C (PLC) and increasing intracellular calcium, leading to the release of ACTH from the pituitary gland. Dysregulation of AVPR1B is associated with stress-related disorders, such as anxiety and depression, and alterations in AVPR1B signaling have been implicated in diseases such as Cushing's syndrome and some forms of neuroendocrine tumors. Targeting AVPR1B with antagonists is being explored for the treatment of stress-related diseases and disorders linked to excessive ACTH secretion.