Mouse Apoptosis Regulator Bcl-2 (BCL2) CLIA Kit
643.5€ (96 tests)
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935106861
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name
Mouse Apoptosis Regulator Bcl-2 (BCL2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx195229
tested applications
CLIA
Description
Mouse B-Cell Leukemia/Lymphoma 2 (Bcl-2) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against B-Cell Leukemia/Lymphoma 2 (Bcl-2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Apoptosis Regulator Bcl-2 (BCL2) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 7.81 pg/ml - 500 pg/ml |
| Sensitivity | 4.69 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P10417 |
| Gene ID | 12043 |
| Alias | Bcl-2,PPP1R50,B-Cell CLL/Lymphoma 2 |
| Background | CLIA Kits BCL2 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
BCL2 apoptosis regulator (BCL2) is a key anti-apoptotic protein that plays a central role in regulating cell survival by preventing mitochondrial-mediated apoptosis BCL2 functions by inhibiting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, thus preventing caspase activation and cell death It is highly expressed in various tissues, particularly in immune cells and neurons, where it protects against apoptosis and supports cell longevity Dysregulation of BCL2 expression has been associated with several diseases, including cancer, where its overexpression allows tumor cells to evade cell death, contributing to tumor progression and resistance to therapy BCL2 is also implicated in neurodegenerative diseases, where its dysfunction can lead to excessive neuronal death BCL2 interacts with other members of the Bcl-2 family, including pro-apoptotic proteins like BAX, to finely tune apoptotic signaling and maintain cellular homeostasis Its role in regulating apoptosis and survival pathways makes BCL2 a critical factor in development, aging, and disease management
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