Mouse Apolipoprotein D (APOD) Protein

Product specifications

Proteins and Peptides

Apolipoprotein D (APOD)

E. coli

Activity: Not tested
Sequence Fragment: Met1-Leu189
Tag: N-terminal His tag and GST tag

Mouse

Unconjugated

Calculated MW: 51.5 kDa  Observed MW (SDS-PAGE): 52 kDa

Recombinant

> 97%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.05% Sarcosyl, 1 mM DTT, 5% Trehalose.

Shipped within 5-7 working days.

Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.

No

P51910

APOD, Apod, apolipoprotein D

Protein APOD

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

Apolipoprotein D (APOD) is a unique member of the apolipoprotein family, functioning as a lipid transporter in the plasma and extracellular fluids. Unlike other apolipoproteins, APOD is not synthesized in the liver but is predominantly produced in the central nervous system (CNS), liver, kidneys, and mammary glands. APOD associates with high-density lipoprotein (HDL) and contributes to cholesterol transport, as well as lipid metabolism. Structurally, APOD is classified as a member of the lipocalin family, which binds small hydrophobic molecules, such as arachidonic acid and cholesterol. It has a prominent role in antioxidant defense by neutralizing reactive oxygen species (ROS) and reducing oxidative stress, particularly in the CNS. APOD is upregulated during injury and neurodegenerative conditions, including Alzheimer’s disease, Parkinson’s disease, and stroke, indicating its neuroprotective function. Elevated levels of APOD are also found in cancer, cardiovascular disease, and diabetes, suggesting its role in cellular stress responses. APOD may regulate inflammation, cellular lipid homeostasis, and signal transduction, making it a promising biomarker and therapeutic target in age-related disorders, metabolic syndromes, and neurological diseases.

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