Mouse Antiviral Innate Immune Response Effector Ifit1 (IFIT1) Protein
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Description
Mouse Antiviral Innate Immune Response Effector IFIT1 (IFIT1) Protein is a recombinant full-length protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Antiviral Innate Immune Response Effector Ifit1 (IFIT1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: 1-463 AA Tag: C-terminal His tag |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 60.7 kDa |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Tested Applications | SDS-PAGE |
| Buffer | Tris/PBS based, containing 50% glycerol. |
| Availability | Shipped within 15-25 working days. |
| Storage | Aliquot and store at -20 °C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q64282 |
| Gene ID | 15957 |
| Background | Protein IFIT1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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Human IFIT1 (Interferon-induced protein with tetRatricopeptide repeats 1) ELISA Kit
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IFIT1 antibody
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group(PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
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