Mouse Anoctamin 1 (ANO1) Protein

Este producto es parte de ANO - Anoctamin
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234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Anoctamin 1 (ANO1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167323
tested applications
WB, SDS-PAGE

Description

Mouse Anoctamin 1 Protein is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Anoctamin 1 (ANO1)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 28.4 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Ser20-Val239

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q8BHY3
Gene ID
101772
Alias
ANO1,DOG1,ORAOV2,TAOS2,TMEM16A
Background
Protein ANO1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ANO1, also known as TMEM16A, is a calcium-activated chloride channel (CaCC) that plays a critical role in regulating chloride ion transport across membranes. It is widely expressed in epithelial cells, smooth muscle, and sensory neurons, where it regulates functions such as fluid secretion, smooth muscle contraction, and sensory transduction. ANO1 is essential for maintaining proper secretion of fluids and electrolytes in tissues such as the respiratory tract, salivary glands, and intestines. Dysregulation of ANO1 has been associated with diseases like cystic fibrosis, where chloride transport is impaired, as well as cancer, particularly in promoting tumor cell proliferation and migration. ANO1 also contributes to neuronal excitability and pain sensation, making it a potential therapeutic target in disorders involving abnormal ion transport and smooth muscle dysfunction.

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