Mouse Ankyrin Repeat Domain Protein 1 (ANKRD1) Protein
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Description
Ankyrin Repeat Domain Protein 1 is a recombinant Mouse protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Ankyrin Repeat Domain Protein 1 (ANKRD1) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 39.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Phe319 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ALRP,C-193,CARP,CVARP |
| Background | Protein ANKRD1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ANKRD1, also known as Cardiac Ankyrin Repeat Protein (CARP), is a transcriptional regulator predominantly expressed in cardiac and skeletal muscles. It localizes to the nucleus and sarcomere, where it interacts with structural proteins like titin and myopalladin. ANKRD1 functions as a stress response protein, upregulated during mechanical stress, injury, and pathological remodeling of the heart. It regulates gene expression through its interaction with transcription factors and participates in processes such as cardiomyocyte differentiation, sarcomeric assembly, and cellular mechanosensing. Mutations or dysregulation of ANKRD1 are associated with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), where it contributes to altered heart function and structure. ANKRD1 also plays a role in fibrosis, angiogenesis, and cellular signaling pathways activated during heart failure and stress adaptation, making it a potential biomarker for cardiac disorders.
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