Mouse Ankyrin-3 (ANK3) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Ankyrin-3 (ANK3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501740
tested applications
ELISA
Description
Mouse Ankyrin-3 (ANK3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Ankyrin-3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Ankyrin-3 (ANK3) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | G5E8K5 |
| Gene ID | 11735 |
| Alias | Ankyrin-G |
| Background | Elisa kits for ANK3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANK3, also known as ankyrin-G, is a member of the ankyrin protein family that functions as a cytoskeletal adaptor protein, organizing and stabilizing membrane domains by linking integral membrane proteins to the spectrin-actin cytoskeleton. ANK3 is highly expressed in the nervous system, where it is critical for the proper localization and clustering of ion channels and adhesion molecules in neurons, particularly at the nodes of Ranvier and axon initial segments (AIS). This localization is essential for the initiation and propagation of action potentials, supporting neuronal excitability and communication. ANK3 also plays a role in synaptic stability and organization, contributing to proper brain development and function. Mutations in ANK3 are associated with neurological and psychiatric disorders, including bipolar disorder, schizophrenia, and autism spectrum disorders, where disruptions in neuronal signaling and ion channel organization occur. In cardiac muscle, ANK3 anchors critical ion channels and structural proteins, making it essential for maintaining cardiac excitability and rhythm. Dysregulation of ANK3 can lead to cardiac arrhythmias and neurodevelopmental abnormalities, highlighting its importance in both neuronal and cardiac cellular organization and function.
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