Mouse Angiotensin I Converting Enzyme 2 (ACE2) Protein
832€ (20 µg)
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935106861
info@markelab.com
name
Mouse Angiotensin I Converting Enzyme 2 (ACE2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692741
tested applications
SDS-PAGE
Description
Mouse ACE2 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse ACE2 isoform 1 (Q8R0I0-1) extracellular domain (Met 1-Thr 740) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ACE2 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 112 kDa Sequence Fragment: Met1-Thr740 Tag: C-terminal His tag and Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 150mM NaCl, 1mM ZnCl2, pH 7.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8R0I0-1 |
| Alias | ACEH,Peptidyl-Dipeptidase A |
| Background | Protein ACE2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Angiotensin I Converting Enzyme 2 (ACE2) is a transmembrane protein that serves as a key regulator of the renin-angiotensin system (RAS) by catalyzing the conversion of angiotensin II (a potent vasoconstrictor) into angiotensin 1-7, which has vasodilatory, anti-inflammatory, and anti-fibrotic effects. ACE2 is highly expressed in the lungs, heart, kidneys, and gastrointestinal tract, and it plays a crucial role in maintaining cardiovascular and pulmonary homeostasis. Beyond its enzymatic function, ACE2 gained significant attention as the cellular entry receptor for the SARS-CoV and SARS-CoV-2 viruses, where it facilitates viral binding and internalization via interactions with the viral spike (S) protein. Dysregulation of ACE2 expression has been implicated in conditions such as hypertension, heart failure, acute lung injury, and COVID-19-related complications. Therapeutic strategies targeting ACE2, such as recombinant soluble ACE2 and RAS modulators, are being explored to counteract these pathologies. ACE2's dual role in regulating vascular function and serving as a viral receptor highlights its significance in both physiology and disease.
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