Mouse Amyloid-beta Precursor Protein (APP) Protein

Este producto es parte de APP - Beta-Amyloid Precursor Protein
Mouse Amyloid-beta Precursor Protein (APP) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein APP

proveedor

Abbexa

reference

abx065298

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Amyloid-beta Precursor Protein (APP) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

APP is a transmembrane glycoprotein widely expressed in the brain and peripheral tissues that plays a critical role in neuronal development, synaptic plasticity, and cell adhesion APP is proteolytically processed by enzymes such as α-secretase, β-secretase, and γ-secretase, leading to the production of various fragments, including the beta-amyloid (Aβ) peptide Abnormal processing of APP and the accumulation of Aβ peptides form amyloid plaques, which are a hallmark of Alzheimer’s disease and contribute to neurotoxicity and neurodegeneration APP also interacts with various proteins to mediate intracellular signaling and cellular responses Mutations in the APP gene are associated with early-onset familial Alzheimer’s disease, highlighting its role in the pathogenesis of neurodegenerative disorders

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Amyloid-beta Precursor Protein (APP)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 12.5 kDa Observed MW (SDS-PAGE): 12 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp672-Asn770 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

APP


dry ice

No


availability

Shipped within 5-7 working days.


alias

AAA,AD1,PN2,ABPP,APPI,CVAP,ABETA,PN-II,preA4,CTFgamma,alpha-sAPP,Alzheimer disease amyloid protein


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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