Mouse Aminoadipate Semialdehyde Synthase (AASS) Protein

Este producto es parte de AASS - Alpha-aminoadipic semialdehyde synthase mitochondrial
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234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Aminoadipate Semialdehyde Synthase (AASS) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650212
tested applications
WB, SDS-PAGE

Description

Mouse AASS Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Aminoadipate Semialdehyde Synthase (AASS)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 52.8 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Met477-Leu926

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q99K67
Alias
LKRSDH,LORSDH,LKR/SDH
Background
Protein AASS
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Alpha-aminoadipic semialdehyde synthase (AASS) is a bifunctional mitochondrial enzyme involved in the lysine degradation pathway. It catalyzes two sequential reactions: the oxidation of lysine to saccharopine via its lysine-ketoglutarate reductase activity and the subsequent conversion of saccharopine to alpha-aminoadipic semialdehyde via saccharopine dehydrogenase activity. This pathway plays a crucial role in amino acid catabolism and the production of acetyl-CoA, linking it to energy metabolism and the tricarboxylic acid (TCA) cycle. AASS is essential for maintaining lysine homeostasis and energy production, particularly under conditions of low glucose availability. Mutations in the AASS gene can lead to hyperlysinemia, a metabolic disorder characterized by elevated lysine levels in the blood and associated neurological symptoms. Emerging studies suggest AASS may also play a regulatory role in mitochondrial function and oxidative stress responses.

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