Mouse Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) ELISA Kit

Este producto es parte de ALKBH - alkB homolog
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715€ (96 tests)

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935106861
info@markelab.com
name
Mouse Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501554
tested applications
ELISA

Description

Mouse Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q6P6J4
Gene ID
231642
Alias
ALKBH2,ABH2
Background
Elisa kits for ALKBH2
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ALKBH2 is a key DNA repair enzyme that catalyzes the direct reversal of methylated lesions, particularly N1-methyladenine (m1A) and N3-methylcytosine (m3C), in double-stranded DNA. It is part of the alpha-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase family, where it utilizes α-KG and molecular oxygen to demethylate damaged bases. ALKBH2 is essential for maintaining genomic integrity, as it repairs alkylation damage caused by environmental mutagens, chemotherapeutic agents, and endogenous metabolism. It operates in coordination with other DNA repair pathways to prevent mutations and DNA strand breaks. ALKBH2 is particularly active during DNA replication and cell division, ensuring faithful genome transmission. Mutations or dysregulation of ALKBH2 are associated with increased susceptibility to cancer and reduced cellular survival under genotoxic stress. Its function makes it a promising therapeutic target for enhancing the efficacy of alkylating agents in cancer treatment.

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