Mouse Alanine--TRNA Ligase, Cytoplasmic (AARS1) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Mouse AARS Protein is a recombinant protein from Mouse produced in Baculovirus-Insect Cells. A DNA sequence encoding the mouse AARS (Q8BGQ7) (Met 1-Asn 968) was fused with a polyhistidine tag at the C-terminus.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Alanine--TRNA Ligase, Cytoplasmic (AARS1) |
| Host | Insect |
| Origin | Mouse |
| Observed MW | Molecular Weight: 108.3 kDa Sequence Fragment: Met1-Asn968 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 88% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8BGQ7 |
| Alias | AARS1,AARS |
| Background | Protein AARS1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Alanine-tRNA ligase, encoded by the genes AARS1 (cytoplasmic) and AARS2 (mitochondrial), is a member of the aminoacyl-tRNA synthetase (aaRS) family. These enzymes are crucial for protein synthesis, catalyzing the attachment of alanine to its corresponding tRNA (tRNA^Ala) in a process known as tRNA aminoacylation. This reaction is an essential step in the translation process, ensuring accurate incorporation of alanine into nascent polypeptides according to the genetic code.AARS1 functions in the cytoplasm and is involved in general protein synthesis and AARS2 operates in mitochondria, where it is critical for mitochondrial protein synthesis, essential for maintaining respiratory chain function.The genes encoding these enzymes are conserved across species, reflecting their indispensable role in cellular physiology. Mutations in these genes are associated with various diseases, including neurodegenerative disorders, mitochondrial dysfunction, and cancer.
Related Products
AARS1 antibody
AARS(alanyl-tRNA synthetase) is also named as AlaRS(alanine tRNA ligase 1, cytoplasmic), renal carcinoma antigen NY-REN-42 and belongs to the class-II aminoacyl-tRNA synthetase family. It can interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. AARS consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs(PMID:19661429).
Ver Producto
Alanine--TRNA Ligase, Cytoplasmic (AARS1) Antibody
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes.Class II tRNA synthases evolved early in evolution and are highly conserved.This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein.tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons.They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
Ver Producto
Alanine--TRNA Ligase, Cytoplasmic (AARS1) Antibody
Alanyl-tRNA Synthetase Antibody is a Rabbit Polyclonal antibody against Alanyl-tRNA Synthetase.
Ver Producto