Mouse Aflatoxin B1 Aldehyde Reductase Member 2 (AKR7A2) ELISA Kit

Este producto es parte de AKR7 - Aflatoxin B1 aldehyde reductase member
Mouse Aflatoxin B1 Aldehyde Reductase Member 2 (AKR7A2) ELISA Kit
715€ (96 tests)

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Name
Mouse Aflatoxin B1 Aldehyde Reductase Member 2 (AKR7A2) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx388545
Tested Applications
ELISA

Description

Mouse Aflatoxin B1 Aldehyde Reductase Member 2 (AKR7A2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse AKR7A2 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Aflatoxin B1 Aldehyde Reductase Member 2 (AKR7A2)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
78 pg/ml - 5000 pg/ml
Sensitivity
< 46.9 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q8CG76
Gene ID
110198
Alias
AKR7A2,AFAR,AFAR1,AKR7
Background
Elisa Kits for: AKR7A2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

AKR7A2 is a member of the aldo-keto reductase superfamily that plays a central role in detoxifying harmful aldehydes, including those generated from reactive oxygen species (ROS) and environmental toxins. It specifically reduces aflatoxin B1-dialdehyde, a highly toxic metabolite produced from aflatoxin exposure, into its less reactive alcohol form, protecting cells from aflatoxin-induced damage. AKR7A2 is highly expressed in the liver, kidneys, and gastrointestinal tract, where it safeguards against toxic metabolites arising from dietary toxins, such as aflatoxins, and endogenous lipid peroxidation products like 4-hydroxynonenal (4-HNE). It is also involved in detoxifying aldehydes produced during ethanol metabolism, linking it to alcohol-induced liver injury prevention. AKR7A2 has antioxidant properties that help maintain cellular redox balance under oxidative stress. Dysregulation of AKR7A2 can lead to increased susceptibility to aflatoxin-induced liver carcinogenesis, as inefficient detoxification exacerbates DNA damage and mutagenesis. Recent studies highlight its potential as a protective factor against environmental toxins and as a therapeutic target for liver disease prevention.

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