Mouse Adenosylhomocysteinase (AHCY) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Adenosylhomocysteinase (AHCY) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx254911
tested applications
ELISA
Description
Mouse Adenosylhomocysteinase (AHCY) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Adenosylhomocysteinase concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Adenosylhomocysteinase (AHCY) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P50247 |
| Alias | SAHH,adoHcyase |
| Background | Elisa kits for AHCY |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AHCY, also known as S-adenosylhomocysteine hydrolase, is a critical enzyme in the methionine cycle that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) into homocysteine and adenosine. This reaction is essential for maintaining cellular methylation reactions, as SAH is a potent inhibitor of methyltransferases. AHCY is ubiquitously expressed and localized in the cytoplasm and nucleus, where it regulates methylation-dependent processes such as DNA and histone modification, gene expression, and cell signaling. Dysregulation of AHCY leads to the accumulation of SAH, disrupting methylation and contributing to diseases such as homocystinuria, cardiovascular disease, and neurodegenerative disorders. Mutations in the AHCY gene can cause autosomal recessive hypermethioninemia. AHCY is also being studied as a potential target in cancer and metabolic disorders due to its pivotal role in methylation homeostasis.
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Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
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