Mouse Aconitate Hydratase, Mitochondrial (ACO2) Protein
1235€ (100 µg)
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Name
Mouse Aconitate Hydratase, Mitochondrial (ACO2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx693627
Tested Applications
SDS-PAGE
Description
Aconitate Hydratase, Mitochondrial (ACO2) protein is a recombinant Mouse protein expressed in Insect.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Aconitate Hydratase, Mitochondrial (ACO2) |
| Host | Insect |
| Assay Type | Activity: Not tested Sequence Fragment: Gln28-Gln780 Tag: N-terminal His tag and GST tag |
| Origin | Mouse |
| Observed MW | 110 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile 50 mM Tris, 100 mM NaCl, 10% glycerol, 0.5 mM GSH, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q99KI0 |
| Alias | ICRD,OCA8,OPA9,ACONM,HEL-S-284 |
| Background | Protein ACO2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
Aconitase 2 (ACO2) is a mitochondrial enzyme involved in the tricarboxylic acid (TCA) cycle, where it catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. ACO2 is essential for cellular energy production, linking carbohydrate metabolism to the production of reducing equivalents such as NADH and FADH2. The enzyme contains an iron-sulfur cluster that is critical for its catalytic activity but also makes it sensitive to oxidative damage, which can impair function. Mutations or dysregulation of ACO2 are associated with mitochondrial diseases, neurodegenerative disorders such as Parkinson's disease, and aging, as oxidative stress often leads to loss of aconitase activity. ACO2 is also being explored as a biomarker for mitochondrial dysfunction in metabolic and neurological conditions.
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