Mouse A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10) ELISA Kit

Product specifications

ELISA Kits

A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10)

Mouse

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Serum, plasma and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P58459

224697

Type 1 Motif 10,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10,WMS,WMS1,ADAMTS-10,ADAM-TS10

Elisa kits for ADAMTS10

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10) is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS10 contains several domains, including a signal peptide, a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and multiple thrombospondin type 1 (TSP1) motifs. ADAMTS10 plays a crucial role in ECM remodeling by cleaving ECM proteins such as aggrecan, versican, and brevican. ADAMTS10 is implicated in embryonic development, particularly in skeletal development. It is involved in processes such as chondrogenesis and osteogenesis , where it regulates ECM composition and structure. Mutations in the ADAMTS10 gene have been associated with human genetic disorders such as Weill-Marchesani syndrome (WMS) and geleophysic dysplasia (GD). These disorders are characterized by skeletal abnormalities, short stature, and other connective tissue abnormalities. ADAMTS10 gene mutations can also cause GD, another rare connective tissue disorder characterized by short stature, joint contractures, and cardiac abnormalities. Like in WMS, mutations in ADAMTS10 disrupt normal ECM remodeling and tissue development, leading to the characteristic features of GD.ADAMTS10 expression levels have been found to be dysregulated in various cancers, including breast cancer, colon cancer, and gastric cancer. Its roles in ECM remodeling and tissue development suggest potential contributions to tumor progression, invasion, and metastasis

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