Mouse A Disintegrin And Metalloprotease 10 (ADAM10) Protein

Product specifications

Proteins and Peptides

A Disintegrin And Metalloprotease 10 (ADAM10)

E. coli

Mouse

Unconjugated

Molecular Weight: Calculated MW: 26.2 kDa  Observed MW: 30 kDa  Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed.
Concentration: Prior to lyophilization: 80 µg/ml
Sequence Fragment: Thr423-Asp650
Tag: N-terminal His tag

Recombinant

> 97%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

O35598

11487

MADM, HsT18717,Kuz ,CD156d,AD10,AD18,RAK,KUZ,ADAM-10

Protein ADAM10

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ADAM10, also known as ADAM metallopeptidase domain 10, is a type I transmembrane glycoprotein belonging to the ADAM (a disintegrin and metalloproteinase) family of proteins. It is encoded by the ADAM10 gene located on human chromosome 15. ADAM10 plays crucial roles in various biological processes, including cell adhesion, cell fusion, cell signaling, proteolysis, and ectodomain shedding of membrane proteins. It is involved in the cleavage of a wide range of cell surface proteins, including cytokines, growth factors, adhesion molecules, and receptors. ( Notch receptors, amyloid precursor protein (APP), cadherins, and several cytokines and growth factors). The proteolytic activity of ADAM10 is tightly regulated, as its dysregulation can have significant implications in various diseases, including cancer, Alzheimer's disease, inflammation, and cardiovascular diseases. ADAM10-mediated cleavage of Notch receptors is crucial for various developmental processes, and dysregulation of this process has been implicated in cancer and neurodegenerative diseases. ADAM10 has gained significant attention as a potential therapeutic target for various diseases due to its involvement in critical cellular processes and its ability to modulate the activity of numerous substrates. Inhibition or modulation of ADAM10 activity is being explored as a strategy for the treatment of diseases such as cancer, Alzheimer's disease, and inflammatory disorders

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