MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor (MLLT10) Antibody
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Description
MLLT10 Antibody is a Goat Polyclonal antibody against MLLT10.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor (MLLT10) |
| Host | Goat |
| Reactivity | Rat |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 8028, 17354, 361285 |
| NCBI Accession | NP_004632.1, NP_001009569.1 |
| Background | Antibody anti-MLLT10 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
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MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor (MLLT10) Antibody
Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t (10;11) (p12;q23) translocations. In an analysis of two leukemia patients, the in t (10;11) (p12;q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a predicted 1, 027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t (10;11) (p12;q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10. The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma. GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription. Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.
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