Microtubule-Associated Proteins 1A/1B Light Chain 3A (MAP1LC3A) Antibody

Product Graph
292.5€ (80 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Microtubule-Associated Proteins 1A/1B Light Chain 3A (MAP1LC3A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029963
tested applications
ELISA, WB, IHC

Description

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3c is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Microtubule-Associated Proteins 1A/1B Light Chain 3A (MAP1LC3A)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified Rabbit Polyclonal Antibody.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9BXW4
NCBI Accession
NP_001004343.1
Background
Antibody anti-MAP1LC3A
Status
RUO

Descripción

Related Products

EH2242

Human MAP1LC3A (Microtubule-associated proteins 1A/1B light chain 3A) ELISA Kit

Ver Producto
EM1509

Mouse MAP1LC3A (Microtubule-associated proteins 1A/1B light chain 3A) ELISA Kit

Ver Producto
P0748

Recombinant Human MAP1LC3A

Ver Producto