Methylcytosine Dioxygenase TET3 (TET3) Antibody (Biotin)
169€ (20 µg)
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935106861
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name
Methylcytosine Dioxygenase TET3 (TET3) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx305521
tested applications
ELISA
Description
TET3 Antibody (Biotin) is a Rabbit Polyclonal against TET3 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Methylcytosine Dioxygenase TET3 (TET3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43151 |
| Gene ID | 200424 |
| Alias | FLJ20032, KIAA1546, MDS, Methylcytosine dioxygenase TET2, Nbla00191, Probable methylcytosine dioxygenase TET2, Protein Ayu17 449, Tet 2, Tet methylcytosine dioxygenase 2, Tet oncogene 2, Tet oncogene family member 2, TET2, TET2_HUMAN |
| Background | Antibody anti-TET3 |
| Status | RUO |
Descripción
TET3 is a dioxygenase enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), driving active DNA demethylation and playing a critical role in epigenetic reprogramming. TET3 is predominantly expressed during early embryonic development, oocyte maturation, and zygotic genome activation, where it facilitates global DNA demethylation and ensures proper gene activation for development. In somatic tissues, TET3 is involved in regulating neuronal differentiation, synaptic plasticity, and DNA repair pathways. TET3 plays a pivotal role in brain development and neurogenesis, where it ensures transcriptional flexibility required for cellular identity and maturation. Dysregulation of TET3 has been associated with neurological disorders, aging, and cancer, where altered DNA methylation patterns disrupt gene expression and cellular homeostasis. Knockout studies reveal defects in embryogenesis, impaired neurodevelopment, and increased genomic instability, underscoring TET3's essential role in DNA methylation reprogramming, neuronal function, and developmental regulation.
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