Methylcytosine Dioxygenase TET2 (TET2) Antibody
377€ (100 µg)
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935106861
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name
Methylcytosine Dioxygenase TET2 (TET2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx238603
tested applications
ELISA, WB, IHC
Description
TET2 Antibody is a Rabbit Polyclonal against TET2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Methylcytosine Dioxygenase TET2 (TET2) Immunogen: tet oncogene family member 2 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 224 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6N021 |
| Alias | IMD75,KIAA1546,MDS |
| Background | Antibody anti-TET2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
TET2 is a member of the TET family of dioxygenases that catalyzes the conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) in DNA, promoting active DNA demethylation and epigenetic regulation. TET2 is widely expressed in hematopoietic cells and plays a critical role in stem cell self-renewal, differentiation, and lineage commitment. It acts as a tumor suppressor by maintaining genomic stability and ensuring proper gene expression patterns, particularly in hematopoiesis. Loss-of-function mutations in TET2 are frequently observed in myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and other hematological malignancies, where they disrupt DNA methylation balance, alter gene regulation, and promote uncontrolled proliferation. TET2 also regulates immune responses by modulating T cell differentiation and inflammatory gene expression. Knockout studies in mice demonstrate enhanced hematopoietic stem cell self-renewal, impaired differentiation, and increased susceptibility to leukemogenesis, emphasizing TET2's role in DNA methylation dynamics, tumor suppression, and immune regulation.
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